Leopold Partsi loeng "Understanding what the human genome does?"
Leopold Partsi loeng "Understanding what the human genome does?" (Mida teeb inimese genoom?) toimub 20. novembril kell 11.00 ruumis SCI–109.
Leopold Parts (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, U.K. ) is a geneticist with broad interests in all areas of genomics. He focuses on figuring out most important features to measure in individual cells, creating accurate computational models for their readouts, and finding out how they are changed by genomes and environment.
After double majoring in Computer Science and Mathematics at MIT, Leo received his PhD from the University of Cambridge in 2011 under the supervision of Richard Durbin. In his thesis work, he studied sources of variation in gene expression, as well as using selection to map the genetic basis of fitness traits. This entailed creating probabilistic models of the generative processes, and performing inference in them to estimate the desired properties of the world. The work was awarded the Grand Prize of life sciences PhDs in his native Estonia. After graduation, Leo wanted to train in experimental high throughput genetics, and joined the labs of Brenda Andrews and Charles Boone in the University of Toronto as a Canadian Institute for Advanced Research Global Scholar. In his postdoctoral work, he carried out genome-wide and targeted genetic screens in yeast using collections of fluorescent proteins, and transcriptional modulation using the CRISPR/Cas9 system. He continued his research in systems genetics as a Marie Curie Fellow, completing the second half of the postdoc in the lab of Lars Steinmetz in EMBL Heidelberg and Stanford University.
In the summer of 2015, Leo joined the Sanger Institute faculty as part of the Computational Genomics Programme. His group uses natural and engineered genetic variation, combined with approaches for transcriptional modulation, to identify perturbations that have large effects on cellular traits, such as cell viability, doubling time, or reporter activity.
Pavel Starkov, pavel dot starkov at taltech dot ee